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Expert comment - University of Oxford vaccine announcement

Reaction to the latest news on the COVID-19 vaccine developed by the University of Oxford and AstraZeneca.
Vaccination vials sit on top of two freezer packs in an attempt to keep them cool in the humid climate of the outdoor ward in Basse Hospital, 冈比亚. 信贷:路易斯·利森/ LSHTM

November 2020 has seen Pfizer and BioNTech announce that their ongoing Phase 3 trial of an mRNA vaccine shows 95% effectiveness against COVID-19, and Moderna report that its COVID-19 mRNA vaccine is 94.5%对病毒有效.

现在, the University of Oxford and AstraZeneca have announced that Phase 3 interim analysis indicates their vaccine provides between 62% to 90% protection from the virus.

教授 Peter PiotLSHTM主任说: “2020 will be remembered for the many lives lost from COVID-19, lockdowns and the US election. 现在,科学也应该加入这个名单.

“科学上的突破并不是什么新鲜事, but the importance of the three announcements this month from Pfizer/Biontech, Moderna and today from University of Oxford-AstraZeneca cannot be overestimated.

“The pandemic has taken lives and livelihoods all around the world, turning our way of life upside down in ways we never thought would happen and crippling economies in the process.

“The only way to stop COVID-19 in its tracks is having multiple effective and safe vaccines that can be deployed all around the world and in vast quantities.

“我很高兴看到62%到90%的有效性, 这取决于使用的剂量, 牛津-阿斯利康COVID-19疫苗. The encouraging news is that greater protection at lower dose may mean that more people can be vaccinated with the same amount of vaccines, and that this vaccine can be stored easily at regular fridge temperature. This will also help with equitable access all over the world. I eagerly await to see the data and their implications for deployment of vaccines against COVID-19.

“然而, there are still many hurdles to cross before this pandemic is under control and we can return to normal life. 最重要的是, we must all continue to follow the rules for safe behaviour to suppress the spread of SARS-CoV-2 and save as many lives as possible until we see the full and widespread impact of vaccination. At the same time, urgently addressing vaccine hesitancy is vital.

“然而, November 2020 looks set to be the month that humanity developed the tools to turn the tide against this devastating virus.”

斯蒂芬•埃文斯, 教授 of Pharmacoepidemiology at LSHTM, said“This is good news, even if not as exciting as the news from the mRNA vaccines.

“It is likely that on one dosing regime (from my calculation based on information in the press release rather than what AZ said directly) is that with the smaller group (half/full) there were 3 cases of confirmed COVID-19 in the 2741 giving the vaccine and 29 cases in about the same number given the control (a Meningitis vaccine or placebo). This gives an efficacy close to 90% as reported. In the two full dose regime there were probably 27 cases of Covid in the vaccine group out of 8895 given it, while there were probably 71 cases in the control group. This gives an efficacy close to 62% as reported and combining the data across both groups gives an average of 70.2%. There are statistical uncertainties in each of these numbers and the overall results has a lower bound of over 50% which was a criterion mentioned as being of importance to regulators. There is little doubt that these data meet the criteria, 仅以数字为基础, 对监管部门的批准. Regulators will scrutinise all the detailed data before giving approval.

“真正的好消息是双重的. 首先, the vaccine can be stored in ordinary refrigerators, which helps in high-income countries but is of enormous importance for low-income countries. 其次, the manufacturers and Oxford are committed to making it as easy as possible, 通过世卫组织covid - 19协议, for the vaccine to reach low- and middle income-countries with their pledge to provide the vaccine at cost to such countries not just for the duration of the pandemic but indefinitely.”

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